Publications

See here for a complete list of publications.

2021 submitted Zhou.png
Microenvironmental Sensing by fibroblasts controls tissue composition

Zhou X*, Franklin RA*, Adler M, Carter T, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, and Medzhitov R.

Biorxiv. 2022. https://www.biorxiv.org/content/10.1101/2022.01.18.476683v1

Sensing tissue microenvironment through fibroblast controls population size of macrophages through Hippo-Yap signaling.

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Tissue Homeostasis and Inflammation

Meizlish M*, Franklin R*, Zhou X*, Medzhitov R.

 

Annual Review Immunology. 2021 Apr 26;39:557-581.

We discuss how tissues are organized from a functional perspective and how this helps understand homeostasis, stress and inflammation at tissue level.

2020 iScience Adler.png
Principles of Cell Circuits for Tissue Repair and Fibrosis

Adler M, Mayo A, Zhou X, Franklin R, Meizlish M, Medzhitov R, Kallenberger S, Alon U.

 

iScience. 2020 Feb 21; 23(2).

Myeloid and stromal communication circuitry drives irreversible switch between homeostatic and fibrotic states.

2020 Nat Med Wang.png
Siglec-15 As an Immune Suppressor and Potential Target for Normalization Cancer Immunotherapy

Wang J, Sun JW, Liu L, Flies D, Nie XX, Zhang JP, Song C, Zarr M, Zhou X, Han X, Archer K, O’Neill T, Boto A, Chen LP.

Nature Medicine. 2019 Apr; 25(4):565-666.

Myeloid expression of Siglec15 is a  immune suppressor and provides a novel target for cancer immunotherapy.

2019 Science Signaling Allen.png
Desynchronization of the Molecular Clock Contributes to the Heterogeneity of the Inflammatory Response, 

Allen NC, Philip NH, Hui L, Zhou X, Franklin RA, Kong Y, Medzhitov R.

Science Signaling. 2019 Mar 5; 12(571).

Mammalian circadian clock regulates the the heterogeneity of an inflammatory response at single cell level.

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Adipocyte OGT Governs Diet-Induced Hyperphagia and Obesity,

Li MD, Vera NB, Yang YF, Zhang BC, Ni WM, Ziso-Qejvanaj E, Ding S, Zhang KS, Yin RN, Wang SM, Zhou X, Fang EX, Xu T, Erion DM, Yang XY.

Nature Communications. 2018 Nov 30; 9(1):5103

 

O-GlcNAc transferase promotes transcriptional activation of de novo lipid desaturation in adipose tissue.

2018 Cell Zhou.png
Circuit Design Features of a Stable Two-cell System

Zhou X*, Franklin RA*, Adler M*, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U#, Medzhitov R#.

Cell. 2018 Feb 8; 172(4):744-757.

 

Growth factor communication cell circuit between macrophages and fibroblast can maintain proper population ratios through feedback mechanisms.

See preview by Nicholas Frankel and Windell lim

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Circuits for Homeostasis of Cell-type Ratios Using Growth-factor Endocytosis as a Feedback Mechanism. 

Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U.

PNAS. 2018 Feb 20; 115(8):E1926-E1935.

Circuit modeling reveals endocytosis as a general strategy to achieve a stable two-cell system.

2017 Nat Med Karimy.png
Inflammation-dependent Cerebrospinal Fluid Hypersecretion by the Choroid Plexus Epithelium in Posthemorrhagic Hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nature Medicine. 2017 Aug; 23(8):997-1003.

Intraventricular hemorrhage triggers Toll-like receptor 4-dependent inflammatory response in choroid plexus epithelium.

2016 Elife He.png
Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway.

He B, Zhou X, O’Shea EK.

eLife. 2017 May 9;6:e25157.

Rewiring of transcriptional network markedly altered the spectrum of a cellular response.

2016 Elfe Zhou.png
A Computational Approach to Map Nucleosome Positions and Alternative Chromatin States with Base Pair Resolution.

Zhou X*, Blocker AW*, Airoldi EM#, O'Shea EK#.

eLife. 2016 Sep 13;5:e16970.

A bayesian template-based model reveals eukaryotic chromatin landscape at base-pair resolution.

2014 Elife Su.png
Two-signal Requirement for Growth-promoting Function of Yap in Hepatocytes.

Su T*, Bondar T*, Zhou X, Zhang C, He H, Medzhitov R.

eLife. 2015 Feb 10;4:e02948.

Inflammatory signals synergize with the Hippo-signaling pathway to drive liver cancer.

2011 Mol Cell Zhou.png
Integrated Approaches Reveal Determinants of Genome-wide Binding and Function of the Transcription Factor Pho4.

Zhou X, O’Shea EK.

 

Molecular Cell. 2011 Jun 1;52(3):318-27.

Specificity of transcription program not only requires DNA sequence, but also involves combinatorial epigenetic mechanisms that include restriction by chromatin, competitive and cooperative binding transcription factors. ​

Featured as cover story

 

Molecular Cell

June 1st, 2011.

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