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IMG_1109 2.HEIC

Welcome to the Zhou Lab

We apply interdisciplinary approaches to understand how immune cells interact and communicate with their neighbors and surrounding environment. 

We study tissue-level homeostasis and inflammation 

Research in my lab focuses on elucidating mechanisms regulating tissue homeostasis and inflammation. Mammalian tissues are ecological communities of diverse cell types, including immune cells, stromal cells, neurons, endothelial cells and tissue parenchymal cells. It's becoming clear that Immune cells are integral members of tissue ecosystem. We are interested in studying how immune cells communicate with their tissue neighbors and surrounding environment to maintain homeostatic states of tissues, and how dysregulation of cell-cell and cell-environment interactions may lead to inflammatory disorders. 

We use bottom-up systems approach combined with computational modeling, chemical genetic engineering, high-throughout technologies and in vivo mouse models for an in-depth, quantitative and mechanistic understanding of immunity and tissue ecology. Our current interests include: 1) Identifying mechanisms of controlling the composition and organization of immune cells; 2) Understanding how tissue microenvironment modulates immune functions as a potential strategy to control inflammation; 3) programming genetic and cellular circuits to control immune functions for treating inflammatory disorders and cancer.
Lab News

Jan 1st, 2021


Zhou lab officially opens its door in the Enders Building at Boston Children's Hospital and Harvard Medical School!


Our long-term goal is to decipher molecular and cellular mechanisms regulating tissue homeostasis and inflammation, and to understand how dysregulation of these processes leads to inflammatory disorders.


 We are an interdisciplinary team with expertise across immunology, systems biology, molecular and cellular biology



Boston Children's Hospital

Enders Building 6th floor, 320 Longwood Ave, Boston, MA 02115, USA

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